The 'SEED' in Gundam SEED partially refers to the animation of a seed bursting when a character reaches "SEED mode," but it is also an acronym standing for Superior Evolutionary Element Destined-factor. It is a state acquired in dire situations (i.e. battles) and involves heightened awareness and abilities. It is said to represent the next stage in human evolution. It is not exclusive to Coordinators (Cagalli is a Natural but has the ability). In the series and its spinoffs, the state results in in a change in the appearance of the eyes (the pupils are no longer visible).
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